1a5h
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CATALYTIC DOMAIN OF HUMAN TWO-CHAIN TISSUE PLASMINOGEN ACTIVATOR COMPLEX OF A BIS-BENZAMIDINE
| Authors | Renatus, M. Bode, W. Huber, R. Sturzebecher, J. Prasa, D. Fischer, S. Kohnert, U. Stubbs, M.T. |
| Citation | Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors. |
| Release date | 2000-05-10 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 2.9 Å |
| Classification | HYDROLASE |
Sequence
Chain A (252 residues): Blast Uniprot EC 3.4.21.68IKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVE KYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRL YPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVT NYLDWIRDNMRPChain B (252 residues): Blast Uniprot EC 3.4.21.68
IKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVE KYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRL YPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVT NYLDWIRDNMRPChain C (7 residues): Blast Uniprot EC 3.4.21.68
TCGLRQYChain D (7 residues): Blast Uniprot EC 3.4.21.68
TCGLRQY
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| Databases | Visualization tools | Analysis tools | Quarternary structure |
|---|---|---|---|
Categories: A5 | PDB entry | X-RAY DIFFRACTION | HYDROLASE | HOMO SAPIENS | 2000 | EC 3.4.21.68
