1aoe
From PDBWiki
CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) AND 1,3-DIAMINO-7-(1-ETHYEPROPYE)-7H-PYRRALO-[3,2-F]QUINAZOLINE (GW345)
| Authors | Whitlow, M. Howard, A.J. Stewart, D. Hardman, K.D. Kuyper, L.F. Baccanari, D.P. Fling, M.E. Tansik, R.L. |
| Citation | X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex. |
| Release date | 1998-01-07 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 1.6 Å |
| Classification | OXIDOREDUCTASE |
Sequence
Chain A (192 residues): Blast Uniprot EC 1.5.1.3MLKPNVAIIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWESIPQKFRPLPDRLNIILSRS YENEIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNELINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQP KSELQKFVGDTVLEDDIKEGDFTYNYTLWTRKChain B (192 residues): Blast Uniprot EC 1.5.1.3
MLKPNVAIIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWESIPQKFRPLPDRLNIILSRS YENEIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNELINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQP KSELQKFVGDTVLEDDIKEGDFTYNYTLWTRK
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