1e7w
From PDBWiki
ONE ACTIVE SITE, TWO MODES OF REDUCTION CORRELATE THE MECHANISM OF LEISHMANIA PTERIDINE REDUCTASE WITH PTERIN METABOLISM AND ANTIFOLATE DRUG RESISTANCE IN TRPANOSOMES
| Authors | Gourley, D.G. Schuttelkopf, A.W. Leonard, G.A. Luba, J. Hardy, L.W. Beverley, S.M. Hunter, W.N. |
| Citation | Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites. PubMed |
| Release date | 2002-01-17 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 1.75 Å |
| Classification | DIHYDROFOLATE REDUCTASE |
Sequence
Chain A (291 residues): Blast Uniprot EC 1.5.1.33GSHMTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVSGA DGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKA FAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAV WEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRAChain B (291 residues): Blast Uniprot EC 1.5.1.33
GSHMTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVSGA DGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKA FAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAV WEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
User comments
Links
Search for 1e7w in:
| Databases | Visualization tools | Analysis tools | Quarternary structure |
|---|---|---|---|
