1hfp

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1hfp

COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE

Authors Cody, V. Galitsky, N. Luft, J.R. Pangborn, W. Blakley, R.L. Gangjee, A.
Citation Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
Release date 1998-01-28
Exp. Method X-RAY DIFFRACTION
Resolution 2.1 Å
Classification OXIDOREDUCTASE

Sequence

Chain A (186 residues): Blast Uniprot EC 1.5.1.3
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEGRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELK
EPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLP
EYPGVLSDVQEEKGIKYKFEVYEKND


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