1ia4
From PDBWiki
Candida albicans dihydrofolate reductase complex in which the dihydronicotinamide moiety of dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) is displaced by 5-{[4-(4-MORPHOLINYL)PHENYL]SULFANYL}-2,4-QUINAZOLINEDIAMIN (GW2021)
| Authors | Whitlow, M. Howard, A.J. Stewart, D. Hardman, K.D. Chan, J.H. Baccanari, D.P. Tansik, R.L. Hong, J.S. Kuyper, L.F. |
| Citation | X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH is Displaced by an inhibitor |
| Release date | 2005-04-05 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 1.85 Å |
| Classification | OXIDOREDUCTASE |
Sequence
Chain A (192 residues): Blast Uniprot EC 1.5.1.3MLKPNVAIIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWESIPQKFRPLPDRLNIILSRS YENEIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNELINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQP KSELQKFVGDTVLEDDIKEGDFTYNYTLWTRKChain B (192 residues): Blast Uniprot EC 1.5.1.3
MLKPNVAIIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWESIPQKFRPLPDRLNIILSRS YENEIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNELINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQP KSELQKFVGDTVLEDDIKEGDFTYNYTLWTRK
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