1k27

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1k27

Crystal Structure of 5'-Deoxy-5'-Methylthioadenosine Phosphorylase in Complex with a Transition State Analogue

Authors Singh, V. Shi, W. Evans, G.B. Tyler, P.C. Furneaux, R.H. Almo, S.C. Schramm, V.L.
Citation Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A PubMed
Release date 2005-01-25
Exp. Method X-RAY DIFFRACTION
Resolution 1.95 Å
Classification TRANSFERASE

Sequence

Chain A (283 residues): Blast Uniprot EC 2.4.2.28
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWA
LKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLG
LRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTL
KENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH


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