1kfu

From PDBWiki

Authors	Strobl, S. Fernandez-Catalan, C. Braun, M. Huber, R. Masumoto, H. Nakagawa, K. Irie, A. Sorimachi, H. Bourenkow, G. Bartunik, H. Suzuki, K. Bode, W.
Citation	The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
Release date	2001-12-07
Exp. Method	X-RAY DIFFRACTION
Resolution	2.5 Å
Classification	HYDROLASE

Sequence

Chain L (699 residues): Blast Uniprot EC 3.4.22.53

AGIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGMRWKRPTEI
CADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTK
DGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCS
IDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHED
GEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDG
ESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGE
YILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGVRRLFAQLAGEDAEISAFELQTILRRVL
AKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQ
LHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL

Chain S (184 residues): Blast Uniprot

THYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEF
KYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFK
SLDKDGTGQIQVNIQEWLQLTMYS

User comments

Splice variants

This is one of the few examples where structures for different transcripts of the same protein are available:

ensembl transcript id	uniprot id	pdb code
ENST00000366869	CAN2_HUMAN	1kfu
ENST00000366869	CAN2_HUMAN	1kfx
ENST00000295006	CAN2_HUMAN	2nqa

See also [1]

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