1kmv
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HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9662), A LIPOPHILIC ANTIFOLATE
| Authors | Klon, A.E. Heroux, A. Ross, L.J. Pathak, V. Johnson, C.A. Piper, J.R. Borhani, D.W. |
| Citation | Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution. PubMed |
| Release date | 2003-04-01 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 1.05 Å |
| Classification | OXIDOREDUCTASE |
Sequence
Chain A (186 residues): Blast Uniprot EC 1.5.1.3VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELK EPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLP EYPGVLSDVQEEKGIKYKFEVYEKND
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Categories: KM | PDB entry | X-RAY DIFFRACTION | OXIDOREDUCTASE | HOMO SAPIENS | 2003 | EC 1.5.1.3
