1kr3
From PDBWiki
Crystal Structure of the Metallo beta-Lactamase from Bacteroides fragilis (CfiA) in Complex with the Tricyclic Inhibitor SB-236050.
| Authors | Payne, D.J. Hueso-Rodrguez, J.A. Boyd, H. Concha, N.O. Janson, C.A. Gilpin, M. Bateson, J.H. Cheever, C. Niconovich, N.L. Pearson, S. Rittenhouse, S. Tew, D. Dez, E. Prez, P. de la Fuente, J. Rees, M. Rivera-Sagredo, A. |
| Citation | Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases PubMed |
| Release date | 2003-01-08 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 2.5 Å |
| Classification | HYDROLASE |
Sequence
Chain A (232 residues): Blast Uniprot EC 3.5.2.6AQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVINNHQAALLDTPINDAQTEMLVNWVTDSLHAKVTTFIP NHWHGDCIGGLGYLQRKGVQSYANQMTIDLAKEKGLPVPEHGFTDSLTVSLDGMPLQCYYLGGGHATDNIVVWLPTENIL FGGCMLKDNQATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHTKQIVNQYIESTSKPChain B (232 residues): Blast Uniprot EC 3.5.2.6
AQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVINNHQAALLDTPINDAQTEMLVNWVTDSLHAKVTTFIP NHWHGDCIGGLGYLQRKGVQSYANQMTIDLAKEKGLPVPEHGFTDSLTVSLDGMPLQCYYLGGGHATDNIVVWLPTENIL FGGCMLKDNQATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHTKQIVNQYIESTSKP
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