1ly4

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1ly4

Analysis of quinazoline and PYRIDO[2,3D]PYRIMIDINE N9-C10 reversed bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase

Authors Cody, V. Galitsky, N. Luft, J.R. Pangborn, W. Queener, S.F. Gangjee, A.
Citation Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.
Release date 2005-04-12
Exp. Method X-RAY DIFFRACTION
Resolution 2.1 Å
Classification OXIDOREDUCTASE

Sequence

Chain A (206 residues): Blast Uniprot EC 1.5.1.3
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVI
TRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKF
RDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL


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