1s1r

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1s1r

Crystal structures of prostaglandin D2 11-ketoreductase (AKR1C3) in complex with the non-steroidal anti-inflammatory drugs flufenamic acid and indomethacin

Authors Lovering, A.L. Ride, J.P. Bunce, C.M. Desmond, J.C. Cummings, S.M. White, S.A.
Citation Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. PubMed
Release date 2004-03-23
Exp. Method X-RAY DIFFRACTION
Resolution 2.0 Å
Classification OXIDOREDUCTASE

Sequence

Chain A (331 residues): Blast Uniprot EC 1.-.-.-, 1.1.1.188, 1.1.1.213, 1.1.1.62, 1.3.1.20
MDSKQQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIF
YTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLA
KSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYS
DEYLEHHHHHH


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