1s3y

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1s3y

Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry

Authors Cody, V. Luft, J.R. Pangborn, W. Gangjee, A. Queener, S.F.
Citation Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. PubMed
Release date 2004-03-30
Exp. Method X-RAY DIFFRACTION
Resolution 2.25 Å
Classification OXIDOREDUCTASE

Sequence

Chain A (206 residues): Blast Uniprot EC 1.5.1.3
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVI
TRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKF
RDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL


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