1sha

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CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES

Authors	Waksman, G. Kominos, D. Robertson, S.C. Pant, N. Baltimore, D. Birge, R.B. Cowburn, D. Hanafusa, H. Mayer, B.J. Overduin, M. Resh, M.D. Rios, C.B. Silverman, L. Kuriyan, J.
Citation	Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. PubMed
Release date	1993-10-31
Exp. Method	X-RAY DIFFRACTION
Resolution	1.5 Å
Classification	PHOSPHOTRANSFERASE

Sequence

Chain(s) A (104 residues): Blast Uniprot EC 2.7.1.112

QAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSL
QQLVAYYSKHADGLCHRLTNVCPT

Chain(s) B (5 residues): Blast

XVPML

User comments

Potential modelling error

Looking at the electron density map for this structure, it seems that the N-terminal ALA was modelled incorrectly, because there is no way to place the missing N-terminal GLU without severe clashes. This is probably why it was left out in the structure.