1u71
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Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH
| Authors | Cody, V. Luft, J.R. Pangborn, W. |
| Citation | Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. PubMed |
| Release date | 2005-02-01 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 2.2 Å |
| Classification | OXIDOREDUCTASE |
Sequence
Chain A (186 residues): Blast Uniprot EC 1.5.1.3VGSLNCIVAVSQNMGIGKNGDRPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELK EPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLP EYPGVLSDVQEEKGIKYKFEVYEKND
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| Databases | Visualization tools | Analysis tools | Quarternary structure |
|---|---|---|---|
Categories: U7 | PDB entry | X-RAY DIFFRACTION | OXIDOREDUCTASE | HOMO SAPIENS | 2005 | EC 1.5.1.3
