2a0y

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2a0y

Structure of human purine nucleoside phosphorylase H257D mutant

Authors Murkin, A. Shi, W. Schramm, V.L.
Citation Transition State Inhibitors and Structural analysis of Human PNP Mutants
Release date 2006-06-06
Exp. Method X-RAY DIFFRACTION
Resolution 2.28 Å
Classification TRANSFERASE

Sequence

Chain A (289 residues): Blast Uniprot EC 2.4.2.1
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVM
MQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFP
AMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANDEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS


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