2a1h
From PDBWiki
X-ray crystal structure of human mitochondrial branched chain aminotransferase (BCATm) complexed with gabapentin
| Authors | Goto, M. Miyahara, I. Hirotsu, K. Conway, M. Yennawar, N.H. Islam, M.M. Hutson, S.M. |
| Citation | Crystal Structures of Human Cytosolic and Mitochondrial Branched-Chain Aminotransferases Complexed with the Anticonvulsant Drug, Gabapentin, and Structure of the Cytosolic Enzyme Complexed with 4-Methylvalerate |
| Release date | 2005-09-06 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 1.8 Å |
| Classification | TRANSFERASE |
Sequence
Chain A (365 residues): Blast Uniprot EC 2.6.1.42ASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKA FKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPRR ALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGT MNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPV HRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPVChain B (365 residues): Blast Uniprot EC 2.6.1.42
ASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKA FKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPRR ALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGT MNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPV HRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV
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| Databases | Visualization tools | Analysis tools | Quarternary structure |
|---|---|---|---|
Categories: A1 | PDB entry | X-RAY DIFFRACTION | TRANSFERASE | HOMO SAPIENS | 2005 | EC 2.6.1.42
