2a5u
From PDBWiki
Crystal Structure of human PI3Kgamma complexed with AS605240
| Authors | Camps, M. Ruckle, T. Ji, H. Ardissone, V. Rintelen, F. Shaw, J. Ferrandi, C. Chabert, C. Gillieron, C. Francon, B. Martin, T. Gretener, D. Perrin, D. Leroy, D. Vitte, P.-A. Hirsch, E. Wymann, M.P. Cirillo, R. Schwarz, M.K. Rommel, C. |
| Citation | Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis PubMed |
| Release date | 2005-09-20 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 2.7 Å |
| Classification | Transferase |
Sequence
Chain A (966 residues): Blast Uniprot EC 2.7.1.153MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFI VIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEE IHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVF VEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVRLLY YVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDR VRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSAL DVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSE IAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPES FRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDL CLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL GIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRH HTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA HHHHHH
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| Databases | Visualization tools | Analysis tools | Quarternary structure |
|---|---|---|---|
Categories: A5 | PDB entry | X-RAY DIFFRACTION | TRANSFERASE | HOMO SAPIENS | 2005 | EC 2.7.1.153
