2a6k

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Crystal Structure Analysis of the germline antibody 36-65 Fab in complex with the dodecapeptide SLGDNLTNHNLR

Authors	Sethi, D.K. Agarwal, A. Manivel, V. Rao, K.V. Salunke, D.M.
Citation	Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response. PubMed
Release date	2006-06-13
Exp. Method	X-RAY DIFFRACTION
Resolution	3.0 Å
Classification	IMMUNE SYSTEM

Sequence

Chain(s) P (12 residues): Blast

SLGDNLTNHNLR

Chain(s) A L (214 residues): Blast

DIQMTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISNLEQ
EDIATYFCQQGNTLPRTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL
NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC

Chain(s) B H (222 residues): Blast Uniprot

EVQLQQSGAELVRAGSSVKMSCKASGYTFTSYGINWVKQRPGQGLEWIGYINPGNGYTKYNEKFKGKTTLTVDKSSSTAY
MQLRSLTSEDSAVYFCARSVYYGGSYYFDYWGQGTTLTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTV
TWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRD