2abj
From PDBWiki
Crystal structure of human branched chain amino acid transaminase in a complex with an inhibitor, C16H10N2O4F3SCl, and pyridoxal 5' phosphate.
| Authors | Hu, L.Y. Boxer, P.A. Kesten, S.R. Lei, H.J. Wustrow, D.J. Moreland, D.W. Zhang, L. Ahn, K. Ryder, T.R. Liu, X. Rubin, J.R. Fahnoe, K. Carroll, R.T. Dutta, S. Fahnoe, D.C. Probert, A.W. Roof, R.L. Rafferty, M.F. Kostlan, C.R. Scholten, J.D. Hood, M. Ren, X.D. Schielke, G.P. Su, T.Z. Taylor, C.P. Mistry, A. McConnell, P. Hasemann, C. Ohren, J. |
| Citation | The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases. PubMed |
| Release date | 2006-06-27 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 2.2 Å |
| Classification | TRANSFERASE |
Sequence
Chain A (366 residues): Blast Uniprot EC 2.6.1.42VVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKA FRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPAFIGTEPSLGVKKPTK ALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEDVDNGCQQVLWLYGRDHQITEVGT MNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFSSGTACVVCPV SDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLSChain D (366 residues): Blast Uniprot EC 2.6.1.42
VVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKA FRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPAFIGTEPSLGVKKPTK ALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEDVDNGCQQVLWLYGRDHQITEVGT MNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFSSGTACVVCPV SDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLSChain G (366 residues): Blast Uniprot EC 2.6.1.42
VVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKA FRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPAFIGTEPSLGVKKPTK ALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEDVDNGCQQVLWLYGRDHQITEVGT MNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFSSGTACVVCPV SDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLSChain J (366 residues): Blast Uniprot EC 2.6.1.42
VVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKA FRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPAFIGTEPSLGVKKPTK ALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEDVDNGCQQVLWLYGRDHQITEVGT MNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFSSGTACVVCPV SDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS
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| Databases | Visualization tools | Analysis tools | Quarternary structure |
|---|---|---|---|
Categories: AB | PDB entry | X-RAY DIFFRACTION | TRANSFERASE | HOMO SAPIENS | 2006 | EC 2.6.1.42
