2acu

From PDBWiki

Authors	Bohren, K.M. Grimshaw, C.E. Lai, C.J. Harrison, D.H. Ringe, D. Petsko, G.A. Gabbay, K.H.
Citation	Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme.
Release date	2003-04-01
Exp. Method	X-RAY DIFFRACTION
Resolution	1.76 Å
Classification	OXIDOREDUCTASE

Sequence

Chain A (315 residues): Blast Uniprot EC 1.1.1.21

ASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVHQNENEVGVAIQEKLREQVVKREELFIVSKLWC
TYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISN
FNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKH
NKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF

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