2aow

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Histamine Methyltransferase (Natural Variant I105) Complexed with the Acetylcholinesterase Inhibitor and Altzheimer's Disease Drug Tacrine

Authors	Horton, J.R. Sawada, K. Nishibori, M. Cheng, X.
Citation	Structural basis for inhibition of histamine N-methyltransferase by diverse drugs
Release date	2005-09-13
Exp. Method	X-RAY DIFFRACTION
Resolution	2.97 Å
Classification	TRANSFERASE

Sequence

Chain(s) A B (292 residues): Blast Uniprot EC 2.1.1.8

MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPG
VCINNEVVEPSAEQIAKYKELVAKISNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHS
LLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLL
WDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA