2bm2
From PDBWiki
HUMAN BETA-II TRYPTASE IN COMPLEX WITH 4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE
| Authors | Levell, J. Astles, P. Eastwood, P. Cairns, J. Houille, O. Aldous, S. Merriman, G. Whiteley, B. Pribish, J. Czekaj, M. Liang, G. Maignan, S. Guilloteau, J.P. Dupuy, A. Davidson, J. Harrison, T. Morley, A. Watson, S. Fenton, G. McCarthy, C. Romano, J. Mathew, R. Engers, D. Gardyan, M. Sides, K. Kwong, J. Tsay, J. Rebello, S. Shen, L. Wang, J. Luo, Y. Giardino, O. Lim, H.K. Smith, K. Pauls, H. |
| Citation | Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase. PubMed |
| Release date | 2005-03-22 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 2.2 Å |
| Classification | HYDROLASE |
Sequence
Chain A (245 residues): Blast Uniprot EC 3.4.21.59IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVH PQFYTAQIGADIALLELEEPVKVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDA KYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHY VPKKPChain B (245 residues): Blast Uniprot EC 3.4.21.59
IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVH PQFYTAQIGADIALLELEEPVKVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDA KYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHY VPKKPChain C (245 residues): Blast Uniprot EC 3.4.21.59
IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVH PQFYTAQIGADIALLELEEPVKVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDA KYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHY VPKKPChain D (245 residues): Blast Uniprot EC 3.4.21.59
IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVH PQFYTAQIGADIALLELEEPVKVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDA KYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHY VPKKP
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| Databases | Visualization tools | Analysis tools | Quarternary structure |
|---|---|---|---|
Categories: BM | PDB entry | X-RAY DIFFRACTION | HYDROLASE | HOMO SAPIENS | 2005 | EC 3.4.21.59
