2bmc
From PDBWiki
AURORA-2 T287D T288D COMPLEXED WITH PHA-680632
| Authors | Fancelli, D. Berta, D. Bindi, S. Cameron, A.D. Catana, C. Forte, B. Giordano, P. Mantegani, S. Meroni, M. Moll, J. Pittala, V. Severino, D. Storici, P. Tonani, R. Varasi, M. Vulpetti, A. Vianello, P. Izzo, G. Sagliano, A. Rusconi, L. |
| Citation | Potent and Selective Auroraa Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition |
| Release date | 2005-03-17 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 2.6 Å |
| Classification | TRANSFERASE |
Sequence
Chain A (306 residues): Blast Uniprot EC 2.7.11.1GPQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQ LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDI KPENLLLGSAGELKIADFGWSVHAPSSRRDDLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQET YKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQSChain B (306 residues): Blast Uniprot EC 2.7.11.1
GPQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQ LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDI KPENLLLGSAGELKIADFGWSVHAPSSRRDDLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQET YKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQSChain C (306 residues): Blast Uniprot EC 2.7.11.1
GPQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQ LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDI KPENLLLGSAGELKIADFGWSVHAPSSRRDDLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQET YKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQSChain D (306 residues): Blast Uniprot EC 2.7.11.1
GPQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQ LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDI KPENLLLGSAGELKIADFGWSVHAPSSRRDDLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQET YKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQSChain E (306 residues): Blast Uniprot EC 2.7.11.1
GPQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQ LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDI KPENLLLGSAGELKIADFGWSVHAPSSRRDDLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQET YKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQSChain F (306 residues): Blast Uniprot EC 2.7.11.1
GPQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQ LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDI KPENLLLGSAGELKIADFGWSVHAPSSRRDDLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQET YKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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Categories: BM | PDB entry | X-RAY DIFFRACTION | TRANSFERASE | HOMO SAPIENS | 2005 | EC 2.7.11.1
