2nqa

From PDBWiki

Authors	Davis, T.L. Paramanathan, R. Butler-Cole, C. Finerty Jr., P.J. Weigelt, J. Sundstrom, M. Arrowsmith, C.H. Edwards, A.M. Bochkarev, A. Dhe-Paganon, S.
Citation	Structure of Human Calpain 8
Release date	2006-11-21
Exp. Method	X-RAY DIFFRACTION
Resolution	2.2 Å
Classification	HYDROLASE/HYDROLASE INHIBITOR

Sequence

Chain A (326 residues): Blast

GSNALKYLGQDFKTLRQQCLDSGVLFKDPEFPAXPSALGYKDLGPGSPQTQGIIWKRPTELXPSPQFIVGGATRTDIXQG
GLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSAL
LEKAYAKLNGXYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALXAGSLLGCSIDVYSAAEAEAITSQKLVK
SHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEI
CNLSPD

Chain B (326 residues): Blast

GSNALKYLGQDFKTLRQQCLDSGVLFKDPEFPAXPSALGYKDLGPGSPQTQGIIWKRPTELXPSPQFIVGGATRTDIXQG
GLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSAL
LEKAYAKLNGXYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALXAGSLLGCSIDVYSAAEAEAITSQKLVK
SHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEI
CNLSPD

Chain D (3 residues): Blast

LLR

Chain E (3 residues): Blast

LLR

User comments

Splice variants

This is one of the few examples where structures for different transcripts of the same protein are available:

ensembl transcript id	uniprot id	pdb code
ENST00000366869	CAN2_HUMAN	1kfu
ENST00000366869	CAN2_HUMAN	1kfx
ENST00000295006	CAN2_HUMAN	2nqa

See also [1]

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