2p3t
From PDBWiki
Crystal structure of human factor XA complexed with 3-Chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-6-methoxy-phenyl]-amide
| Authors | Ye, B. Arnaiz, D.O. Chou, Y.L. Griedel, B.D. Karanjawala, R. Lee, W. Morrissey, M.M. Sacchi, K.L. Sakata, S.T. Shaw, K.J. Wu, S.C. Zhao, Z. Adler, M. Cheeseman, S. Dole, W.P. Ewing, J. Fitch, R. Lentz, D. Liang, A. Light, D. Morser, J. Post, J. Rumennik, G. Subramanyam, B. Sullivan, M.E. Vergona, R. Walters, J. Wang, Y.X. White, K.A. Whitlow, M. Kochanny, M.J. |
| Citation | Thiophene-anthranilamides as highly potent and orally available factor xa inhibitors. |
| Release date | 2008-01-22 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 1.92 Å |
| Classification | BLOOD CLOTTING |
Sequence
Chain A (52 residues): Blast Uniprot EC 3.4.21.6KLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLEChain B (233 residues): Blast Uniprot EC 3.4.21.6
IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRF TKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSS SFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMK
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| Databases | Visualization tools | Analysis tools | Quarternary structure |
|---|---|---|---|
Categories: P3 | PDB entry | X-RAY DIFFRACTION | BLOOD CLOTTING | 2008 | EC 3.4.21.6
