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Human aldose reductase mutant L300P complexed with zopolrestat.

Authors Steuber, H. Heine, A. Podjarny, A. Klebe, G.
Citation Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features. PubMed
Release date 2008-04-01
Exp. Method X-RAY DIFFRACTION
Resolution 1.56 Å
Classification OXIDOREDUCTASE

Sequence

Chain(s) A (316 residues): Blast Uniprot EC 1.1.1.21
MASRILLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLW
CTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGIS
NFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCAPLSCTSHKDYPFHEEF

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