2pdh
From PDBWiki
Human aldose reductase mutant L300P complexed with uracil-type inhibitor at 1.45 A.
| Authors | Steuber, H. Heine, A. Podjarny, A. Klebe, G. |
| Citation | Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features. PubMed |
| Release date | 2008-04-01 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 1.45 Å |
| Classification | OXIDOREDUCTASE |
Sequence
Chain(s) A (316 residues): Blast Uniprot EC 1.1.1.21MASRILLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLW CTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGIS NFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCAPLSCTSHKDYPFHEEF
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