2q59
From PDBWiki
Crystal Structure of PPARgamma LBD bound to full agonist MRL20
| Authors | Bruning, J.B. Chalmers, M.J. Prasad, S. Busby, S.A. Kamenecka, T.M. He, Y. Nettles, K.W. Griffin, P.R. |
| Citation | Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism PubMed |
| Release date | 2007-10-23 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 2.2 Å |
| Classification | Ligand binding protein |
Sequence
Chain A (274 residues): Blast UniprotSNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQ GXQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDF MEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLR QIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLYChain B (274 residues): Blast Uniprot
SNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQ GCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDF MEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLR QIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
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