2r3f

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2r3f

Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor

Authors Fischmann, T.O. Hruza, A. Duca, J.S. Ramanathan, L. Mayhood, T. Windsor, W.T. Le, H.V. Guzi, T.J. Dwyer, M.P. Paruch, K. Doll, R.J. Lees, E. Parry, D. Seghezzi, W. Madison, V.
Citation Structure-guided discovery of cyclin-dependent kinase inhibitors. PubMed
Release date 2008-01-22
Exp. Method X-RAY DIFFRACTION
Resolution 1.5 Å
Classification Transferase

Sequence

Chain(s) A (298 residues): Blast Uniprot EC 2.7.11.22
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF
EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT
HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL


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