2rjp
From PDBWiki
Crystal structure of ADAMTS4 with inhibitor bound
| Authors | Mosyak, L. Georgiadis, K. Shane, T. Svenson, K. Hebert, T. McDonagh, T. Mackie, S. Olland, S. Lin, L. Zhong, X. Kriz, R. Reifenberg, E.L. Collins-Racie, L.A. Corcoran, C. Freeman, B. Zollner, R. Marvell, T. Vera, M. Sum, P.E. Lavallie, E.R. Stahl, M. Somers, W. |
| Citation | Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. PubMed |
| Release date | 2008-01-08 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 2.8 Å |
| Classification | HYDROLASE |
Sequence
Chain A (316 residues): Blast Uniprot EC 3.4.24.82FASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSF CAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHD NSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLT FGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQADYKDDDDKChain B (316 residues): Blast Uniprot EC 3.4.24.82
FASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSF CAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHD NSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLT FGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQADYKDDDDKChain C (316 residues): Blast Uniprot EC 3.4.24.82
FASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSF CAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHD NSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLT FGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQADYKDDDDKChain D (316 residues): Blast Uniprot EC 3.4.24.82
FASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSF CAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHQLGHVFNMLHD NSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLT FGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQADYKDDDDK
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Categories: RJ | PDB entry | X-RAY DIFFRACTION | HYDROLASE | HOMO SAPIENS | 2008 | EC 3.4.24.82 | PDB entry updated
