3bbr

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3bbr

Crystal structure of the iGluR2 ligand binding core (S1S2J-N775S) in complex with a dimeric positive modulator as well as glutamate at 2.25 A resolution

Authors Kaae, B.H. Harpsoe, K. Kastrup, J.S. Sanz, A.C. Pickering, D.S. Metzler, B. Clausen, R.P. Gajhede, M. Sauerberg, P. Liljefors, T. Madsen, U.
Citation Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites PubMed
Release date 2007-12-04
Exp. Method X-RAY DIFFRACTION
Resolution 2.25 Å
Classification MEMBRANE PROTEIN

Sequence

Chain(s) A B (263 residues): Blast Uniprot
GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVY
GKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWT
YMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLK
LSEQGLLDKLKNKWWYDKGECGS


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