3c0o

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Crystal structure of the proaerolysin mutant Y221G complexed with mannose-6-phosphate

Authors	Pernot, L. Schiltz, M. Thurnheer, S. Burr, S.E. van der Goot, G.
Citation	Receptor binding and activation of the pore-forming toxin aerolysin: a crystallographic study
Release date	2008-02-12
Exp. Method	X-RAY DIFFRACTION
Resolution	2.5 Å
Classification	TOXIN

Sequence

Chain(s) A B (470 residues): Blast Uniprot

AEPVYPDQLRLFSLGQGVCGDKYRPVNREEAQSVKSNIVGMMGQWQISGLANGWVIMGPGYNGEIKPGTASNTWCYPTNP
VTGEIPTLSALDIPDGDEVDVQWRLVHDSANFIKPTSYLAHYLGYAWVGGNHSQYVGEDMDVTRDGDGWVIRGNNDGGCD
GYRCGDKTAIKVSNFAYNLDPDSFKHGDVTQSDRQLVKTVVGWAVNDSDTPQSGYDVTLRGDTATNWSKTNTYGLSEKVT
TKNKFKWPLVGETELSIEIAANQSWASQNGGSTTTSLSQSVRPTVPARSKIPVKIELYKADISYPYEFKADVSYDLTLSG
FLRWGGNAWYTHPDNRPNWNHTFVIGPYKDKASSIRYQWDKRYIPGEVKWWDWNWTIQQNGLSTMQNNLARVLRPVRAGI
TGDFSAESQFAGNIEIGAPVPLAADSKVRRARSVDGAGQGLRLEIPLDAQELSGLGFNNVSLSVTPAANQ