3cs7
From PDBWiki
FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-(4-methoxyphenyl)-6-(4-(1-(pyrrolidin-1-ylmethyl)cyclopropyl)phenyl)-3-(trifluoromethyl)-5,6-dihydro-1H-pyrazolo[3,4-c]pyridin-7(4H)-one
| Authors | Qiao, J.X. Cheney, D.L. Alexander, R.S. Smallwood, A.M. King, S.R. He, K. Rendina, A.R. Luettgen, J.M. Knabb, R.M. Wexler, R.R. Lam, P.Y. |
| Citation | Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: discovery of novel, highly potent inhibitors of Factor Xa. PubMed |
| Release date | 2008-07-08 |
| Exp. Method | X-RAY DIFFRACTION |
| Resolution | 2.2 Å |
| Classification | HYDROLASE |
Sequence
Chain(s) A (234 residues): Blast Uniprot EC 3.4.21.6IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRF TKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSS SFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTChain(s) L (52 residues): Blast Uniprot EC 3.4.21.6
KLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLE
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|---|---|---|---|
Categories: CS | PDB entry | X-RAY DIFFRACTION | HYDROLASE | 2008 | EC 3.4.21.6 | PDB entry updated
