3csh

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3csh

Crystal Structure of Glutathione Transferase Pi in complex with the Chlorambucil-Glutathione Conjugate

Authors Parker, L.J. Ciccone, S. Italiano, L.C. Primavera, A. Oakley, A.J. Morton, C.J. Hancock, N.C. Bello, M.L. Parker, M.W.
Citation The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants. PubMed
Release date 2008-07-01
Exp. Method X-RAY DIFFRACTION
Resolution 1.55 Å
Classification TRANSFERASE

Sequence

Chain(s) A B (209 residues): Blast Uniprot EC 2.5.1.18
PPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYG
KDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLL
IHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ

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